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Expression of Caveolin-1 Is Linked to Increased Malignancy and Metastasis of Gallbladder Cancer Cells 1

World Journal of Gastroenterology, Hepatology and Endoscopy (ISSN:2766-788X)

Expression of Caveolin-1 Is Linked to Increased Malignancy and Metastasis of Gallbladder Cancer Cells

Background Gallbladder cancer (GBC), the most common biliary tract malignancy, shows high incidence in Amerindian Chilean women and poor survival rates. Caveolin-1 (CAV1) may act as a tumour sup- pressor or promoter depending on E-cadherin (E-cadh) expres- sion, but its specific role in GBC progression remains unclear. 1.2. Aim 2 To investigate how CAV1 and E-cadh influence metastasis and prognosis in GBC. 

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